Research Group: Sergio Schinelli, Mayra Paolillo

The research project deals with the measurement of adhesion and proliferation of breast cancer stem cells neurospheres, grown as anoikis-resistant neurospheres, to 2D and 3D scaffold loaded with bone and endothelial cells in absence and presence of integrins antagonists.

Recent Publications:

• Integrins in glioblastoma: Still an attractive target? Paolillo M, Serra M, Schinelli S.
  Pharmacol Res. 2016 Nov;113(Pt A):55-61.
• Cyclic isoDGR and RGD peptidomimetics containing bifunctional diketopiperazine scaffolds are integrin antagonists. Panzeri S, Zanella S, Arosio D, Vahdati L, Dal Corso A, Pignataro L, Paolillo M, Schinelli S, Belvisi L, Gennari C, Piarulli U. Chemistry. 2015 Apr 13;21(16):6265-71.
• Effects of a novel cyclic RGD peptidomimetic on cell proliferation, migration and angiogenic activity in human endothelial cells. Fanelli R, Schembri L, Piarulli U, Pinoli M, Rasini E, Paolillo M, Galiazzo MC, Cosentino M, Marino F. Vasc Cell. 2014 May 21;6:11.

Links :
http://www.news-medical.net/life-sciences/2D-and-3D-Cell-Culture-Comparison.aspx
http://onlinelibrary.wiley.com/doi/10.1002/jcp.24683/pdf