Research Group: Mayra Paolillo

The research project deals with the study of NAMPT role in glioblastoma stem cells (GSC) proliferation and infiltration ability in the brain tissue. Human GSC from glioblastoma patients are used as experimental model and new molecules targeting NAMPT are investigated in the aim of limiting GBM spread.

Recent Publications:

• Small Molecules against Metastatic Tumors: Concrete Perspectives and Shattered Dreams. Serra, M., Rubes, D., Schinelli, S., Paolillo, M. Cancers, 2023, 15(16), 4173.
• cRGD-Functionalized Silk Fibroin Nanoparticles: A Strategy for Cancer Treatment with a Potent Unselective Naphthalene Diimide Derivative. Pirota, V., Bisbano, G., Serra, M., Torre, M.L., Doria, F., Bari, E., Paolillo, M. Cancers, 2023, 15(6), 1725.
• RGD Cyclopeptide Equipped with a Lysine-Engaging Salicylaldehyde Showing Enhanced Integrin Affinity and Cell Detachment Potency. Sacco, G., Arosio, D., Paolillo, M., Gloger, A., Scheuermann, J., Pignataro, L., Belvisi, L., Dal Corso, A., Gennari, C. Chemistry – A European Journal, 2023, 29(19), e202203768.

Links :
https://www.cell.com/trends/cancer/fulltext/S2405-8033(20)30025-X
https://www.hopkinsmedicine.org/health/conditions-and-diseases/glioblastoma-multiforme-gbm-advancing-treatment-for-a-dangerous-brain-tumor